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130 Toremifene Citrate Improves High-Density Lipoprotein Levels in Men on Testosterone Replacement Therapy The Journal of Sexual Medicine

130 Toremifene Citrate Improves High-Density Lipoprotein Levels in Men on Testosterone Replacement Therapy The Journal of Sexual Medicine

Vertigo, headache, and dizziness were observed in healthy volunteer studies at a daily dose of 680 mg for 5 days. The symptoms occurred in two of the five subjects during the third day of the treatment and disappeared within 2 days of discontinuation of the drug. No immediate concomitant changes in any measured clinical chemistry parameters were found. In a study in postmenopausal breast cancer patients, toremifene 400 mg/m2 /day caused dose-limiting nausea, vomiting, and dizziness, as well as reversible hallucinations and ataxia in one patient.

  • In this study, we demonstrated that Toremifene Citrate (TOR) inhibited the tube formation and migration of human umbilical vein endothelial cells (HUVEC) in vitro.
  • Discuss the use of birth control, the risks and benefits of this medication, and any other concerns about using this medication with your doctor.
  • The studies included postmenopausal patients with estrogen-receptor (ER) positive or estrogen-receptor (ER) unknown metastatic breast cancer.
  • No immediate concomitant changes in any measured clinical chemistry parameters were found.

Patients should be informed about this and instructed to contact their physician if such bleeding or other gynecological symptoms (changes in vaginal discharge, pelvic pain or pressure) occur. Patients should have a gynecological examination prior to initiation of therapy and at regular intervals while on therapy. Endometrial cancer, endometrial hypertrophy, hyperplasia, and uterine polyps have been reported in some patients treated with FARESTON.

This authentication occurs automatically, and it is not possible to sign out of an IP authenticated account. Toremifene Citrate is usually used to treat cancer that needs estrogen, a female hormone, in order to grow (estrogen-receptor positive). Reference standards of Toremifene Citrate API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below. You are encouraged to report negative side effects of prescription drugs to the FDA.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Discuss the use of birth control, and the risks and benefits of this medication with your doctor. Because of the possible risk to the infant, breastfeeding is not recommended while using this drug. This medicine may increase your risk of having uterus problems, including endometrial cancer. Many drugs besides toremifene may affect the heart rhythm (QT prolongation), including amiodarone, granisetron, pimozide, procainamide, quinidine, sotalol, and macrolide antibiotics (such as erythromycin), among others. Avoid eating grapefruit or drinking grapefruit juice while using this medication unless your doctor or pharmacist says you may do so safely.

So Toremifene Citrate should be avoided in combination with the above drugs. Toremifene Citrate will reduce the renal excretion of calcium drugs, such as thiazide drugs, is the risk of increased hypercalcemia. MyTuftsMed is our new online patient portal that provides you with access to your medical information in one place. MyTuftsMed can be accessed online or from your mobile device providing a convenient way to manage your health care needs from wherever you are. This medicine may be used to treat other conditions as determined by your healthcare provider. The pharmacokinetics of toremifene in patients of different races has not been studied.


Because of the possible risk to the infant, breastfeeding is not recommended while using this medication. Since this drug can be absorbed through the skin and lungs, women who are pregnant or who may become pregnant should not handle this medication or breathe the dust from the tablets. Take this medication by mouth https://cargotrans.vn/new-study-reveals-surprising-effects-of-10/ with or without food as directed by your doctor, usually once daily. The dosage is based on your medical condition and response to treatment. 👇Please click on the image below to directly access the latest data (R&D Status | Core Patent | Clinical Trial | Approval status in Global countries) of this drug.

  • Following coadministration on days 6 and 18 relevant increases in midazolam and α-hydroxymidazolam Cmax and AUC were not observed.
  • Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
  • Patients should have liver function tests performed periodically while on therapy.
  • FARESTON has been shown to prolong the QTc interval in a dose- and concentration-related manner [see CLINICAL PHARMACOLOGY].

If any of these side effects last or get worse, tell your doctor promptly. According to Patsnap Synapse, as of 6 Sep 2023, there are a total of 484 ER drugs worldwide, from 441 organizations, covering 203 indications, and conducting 3875 clinical trials. If you need emergency care, surgery, or dental work, tell the healthcare provider or dentist you are taking this medicine.


If you are a woman who can bear children, your doctor may give you a pregnancy test before you start using this medicine to make sure you are not pregnant. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using this medicine, tell your doctor right away. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

For example, a SERM may act as an estrogen agonist in bone tissue, promoting bone density, while acting as an estrogen antagonist in breast tissue, preventing the growth of cancer cells. ERs modulators are compounds or substances that can interact with and modulate the activity of estrogen receptors (ERs). Estrogen receptors are proteins found in cells that are activated by the hormone estrogen.

Enzyme inducers such as phenobarbital, phenytoin sodium and carbamazepine can increase the metabolic rate of this product and decrease its concentration when it reaches steady state in serum. Toremifene citrate is a selective estrogen receptor modulator (SERM) that binds to estrogen receptors to inhibit the estrogen activity. Along with its needed effects, your medicine may cause some unwanted side effects.

ERs modulators can have different effects on estrogen receptors depending on their specific properties. Some modulators can act as agonists, meaning they bind to the receptors and activate them, mimicking the effects of estrogen. These agonists can be used in hormone replacement therapy to alleviate symptoms of menopause or to treat certain conditions such as osteoporosis.

Toremifene is clastogenic in vitro (chromosomal aberrations and micronuclei formation in human lymphoblastoid MCL-5 cells) and in vivo (chromosomal aberrations in rat hepatocytes). Leukopenia and thrombocytopenia have been reported rarely; leukocyte and platelet counts should be monitored when using FARESTON in patients with leukopenia and thrombocytopenia. Clinically relevant exposure changes in sensitive substrates due to inhibition or induction of CYP3A4 by toremifene appear unlikely. The incidences of the following eight clinical toxicities were prospectively assessed in the North American Study. The incidence reflects the toxicities that were considered by the investigator to be drug related or possibly drug related.

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